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GYKI 52466 dihydrochloride B

CAS No. 2319722-40-0

GYKI 52466 dihydrochloride B( —— )

Catalog No. M32955 CAS No. 2319722-40-0

GYKI 52466 dihydrochloride (GYKI 52466 2HCl) is a highly potent, orally active and selective AMPA/Kainate receptor antagonist with good blood-brain permeability and anticonvulsant activity that can be used to study neurological diseases such as Parkinson's and epilepsy.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GYKI 52466 dihydrochloride B
  • Note
    Research use only, not for human use.
  • Brief Description
    GYKI 52466 dihydrochloride (GYKI 52466 2HCl) is a highly potent, orally active and selective AMPA/Kainate receptor antagonist with good blood-brain permeability and anticonvulsant activity that can be used to study neurological diseases such as Parkinson's and epilepsy.
  • Description
    GYKI 52466 dihydrochloride is an orally active, highly selective and noncompetitive AMPA/kainate receptor antagonist with the IC50 values of 7.5 and 11μM, respectively. GYKI 52466 dihydrochloride has good blood brain barrier permeability and anticonvulsant effect. GYKI 52466 dihydrochloride can be used in Parkinson's disease research.
  • In Vitro
    GYKI 52466 (0.3-100 μM) inhibits inward currents activated by AMPA and Kainate receptor in cultured rat hippocampal neurons.
  • In Vivo
    GYKI 52466 (intraperitoneal injection; 1.76-13.2 mg/kg; once) treatment provides potent anticonvulsant protection against sound-induced seizures in DBA/2 mice.Animal Model:Male and female DBA/2 mice tested for sound-induced seizure responses Dosage:1.76-13.2 mg/kg Administration:Intraperitoneal injection; 1.76-13.2 mg/kg; once Result:Observed Maximal anticonvulsant protection after the i.p. treatment (5-15 min ).
  • Synonyms
    ——
  • Pathway
    Neuroscience
  • Target
    GluR
  • Recptor
    GluR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2319722-40-0
  • Formula Weight
    366.24
  • Molecular Formula
    C17H17Cl2N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 2.78 mg/mL (7.59 mM; Ultrasonic (<60°C)
  • SMILES
    CC1=NN=C(C2=CC=C(N)C=C2)C3=C(C=C4OCOC4=C3)C1.Cl.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. S D Donevan, et al. GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses. Neuron. 1993 Jan;10(1):51-9.?
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